Research shows how the brain physically changes as we learn. Teaching students to learn how to learn while giving instructors the necessary knowledge to redesign their processes is key. We are not proposing a magic solution, but learning mediators are identifying effective tools that can revolutionize the brain for critical thinkers and harness self-regulated students in the process. Through scientific evidence, we can furnish opportunities, activities, values, and the necessary support from educators to identify the most effective educational practices. These identified activities form synapses and connections, besides granting frequent chances to activate related neural circuits that strengthen the brain.